An Alternative Method for the Dissolution of Enrofloxacin Tablets

Enrofloxacin is a fluoroquinolone for veterinary use; it has low aqueous solubility and relatively high permeability. Dissolution may be the limiting step in absorption for solid dosage forms having these characteristics. Considering this, in vitro dissolution tests are indicated to evaluate batch-to-batch quality and to support pharmaceutical equivalence studies. In this study, an alternative dissolution profile was developed for tablets containing enrofloxacin. The selected method uses a 0.01 N HCl medium, paddle apparatus, and 50-rpm speed. The samples were analyzed by UV spectroscopy at 273 nm. The results confirm that the proposed method is suitable for routine quality control of enrofloxacin tablets and the comparison of the dissolution profiles of different commercial formulations.